Aplastic Anaemia Treatment Package
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Written & reviewed by Vikram Kashyap, Medical Consultant, Satyug Healthcare
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| Surgery Name | Cost | Room | Hospitalization |
|---|---|---|---|
| Aplastic Anaemia Treatment Package | 9500 USD | Isolation / BMT Unit Room | ATG: 10-14 days in hospital (4-6 weeks in India); BMT: 30-45 days in hospital (about 90 days in India) |
| Immunosuppressive Therapy (Horse ATG + Cyclosporine) | 9500 USD | Isolation Room | 10-14 days |
| Matched Sibling (Allogeneic) Bone Marrow Transplant | 28000 USD | BMT Unit (HEPA) | 30-45 days |
| Haploidentical / Unrelated Donor BMT | 38000 USD | BMT Unit (HEPA) | 35-50 days |
✓ Inclusion
- ✔Consultations with a senior haematologist
- ✔Admission to an isolation room for about 10–14 days
- ✔Central venous line insertion
- ✔Horse ATG (anti-thymocyte globulin) course as per body weight
- ✔Steroid cover and anti-allergy premedication during ATG
- ✔Cyclosporine started in hospital with drug level monitoring
- ✔Antibiotic, antifungal and antiviral prophylaxis as per protocol during the stay
- ✔Routine blood tests, kidney and liver function during admission
- ✔Standard number of blood and platelet transfusions during the stay
- ✔Nursing care, infection-control measures and patient's meals
- ✔Discharge plan and follow-up schedule with local haematologist
- ✔Free: airport pick-up & drop, visa invitation letter, interpreter & coordinator (Satyug Healthcare)
✗ Exclusion
- ✖Bone marrow biopsy, cytogenetics, NGS, PNH and chromosomal breakage tests
- ✖HLA typing of patient, siblings or family members
- ✖Transfusions beyond the standard package allowance
- ✖Eltrombopag and other add-on medicines
- ✖ICU care, treatment of severe infections or other complications
- ✖Bone marrow transplant (separate package)
- ✖Cyclosporine and other medicines after discharge
- ✖Outpatient blood tests after discharge
- ✖Hotel, food, local travel and flights
- ✖Visa fees and personal expenses
Know More About Procedure & Surgery
🇮🇳 HAEMATOLOGY PACKAGE — INDIA
Aplastic Anaemia Treatment in India
Immunosuppressive therapy with horse ATG and cyclosporine, or a curative bone marrow transplant, for children and adults with severe aplastic anaemia – by experienced haematologists at accredited Indian BMT centres, at a fraction of Western costs.
✅ Free Medical Opinion in 48–72 h🩸 ATG and BMT under one team💰 Starting USD 9,500✈️ Visa & Airport Support🗣️ Interpreter Available
💉
4–5 days
ATG infusion
🏥
10–14 days
Hospital stay (ATG)
📈
60–80%
Respond to ATG
📅
4–6 weeks
In India (ATG)
📖 What is Aplastic Anaemia?
The bone marrow is the soft tissue inside bones that makes all blood cells: red cells (carry oxygen), white cells (fight infection) and platelets (stop bleeding). In aplastic anaemia, the marrow becomes nearly empty and stops making enough of all three. In most cases the body's own immune system attacks the marrow stem cells. It can also follow some medicines, chemicals (such as benzene), viral hepatitis, or be inherited (for example Fanconi anaemia). Patients feel weak and breathless, get repeated infections and bleed easily.
Treatment depends on age, severity and whether a matched donor is available. The two main treatments are immunosuppressive therapy (IST) – a 4–5 day infusion of horse ATG (anti-thymocyte globulin) followed by cyclosporine tablets, often with eltrombopag – which calms the immune attack so the marrow can recover; and a bone marrow (stem cell) transplant (BMT), which replaces the marrow with healthy stem cells from a matched sibling, unrelated or half-matched (haploidentical) family donor and can cure the disease.
🖼️ Understand It in Pictures
💡 In simple words
In aplastic anaemia, the bone marrow stops making enough blood cells: red cells, white cells and platelets. Treatment includes transfusions, medicines that calm the immune system, and a bone marrow transplant, which can cure it.
Normal blood vs aplastic anaemia
👀 Symptoms in Pictures
🩻 Scans & Tests — What Doctors See
🎬 The Treatment Journey in Pictures
📅 Recovery at a Glance
Drawings: Satyug Healthcare (simplified, not to scale). Photos: Wikimedia Commons; author and licence under each photo.
🩺 Conditions Treated
🩸
Severe aplastic anaemia (SAA)
Very low blood counts with neutrophils below 500/µL; needs urgent treatment.
⚠️
Very severe aplastic anaemia (vSAA)
Neutrophils below 200/µL; high infection risk, transplant often preferred.
🧑
Non-severe aplastic anaemia needing transfusions
Moderate disease that is worsening or transfusion-dependent.
🧬
Fanconi anaemia & inherited marrow failure
Inherited forms that do not respond to ATG; transplant with special protocols.
🔁
Relapse or no response after ATG
Second-line treatment or transplant.
🟣
Aplastic anaemia with PNH clone
Marrow failure with a small PNH cell population, monitored and treated together.
⚠️ Symptoms That May Need Treatment
- ➤Extreme tiredness and pale skin
- ➤Breathlessness on mild effort
- ➤Frequent or severe infections and fever
- ➤Easy bruising and small red spots on the skin (petechiae)
- ➤Bleeding gums or nosebleeds
- ➤Heavy menstrual bleeding
- ➤Needing regular blood or platelet transfusions
- ➤Headache or fast heartbeat from anaemia
💡 Not every low blood count is aplastic anaemia. Vitamin B12 or folate deficiency, viral infections, medicines, leukaemia or MDS can look similar, so a bone marrow biopsy is essential. Mild (non-severe) aplastic anaemia that is stable may only need monitoring or cyclosporine alone.
🔬 Tests Before Treatment
| Test | Why it is done |
|---|---|
| Complete blood count and reticulocyte count | Confirms low counts of all cell types and grades severity |
| Bone marrow aspiration and biopsy | Confirms an empty (hypocellular) marrow and rules out leukaemia/MDS |
| Cytogenetics and NGS mutation panel | Looks for MDS and clonal changes |
| PNH flow cytometry | Checks for a PNH clone |
| Chromosomal breakage test (DEB/MMC) | Rules out Fanconi anaemia, especially in children and young adults |
| HLA typing of patient and siblings | Finds a matched donor for transplant |
| Viral screening, liver and kidney function | Hepatitis and infection screening; fitness for treatment |
🏥 The Procedure — Step by Step
1
Haematology consultation
Review of blood counts, marrow reports and family history; severity is graded.
2
Diagnostic work-up
Bone marrow biopsy, PNH test, genetic tests and HLA typing of patient and siblings.
3
Treatment decision
Matched sibling + age under about 40 → transplant usually advised; otherwise ATG-based IST.
4
Admission to isolation room
Central line placed; infection prevention and transfusions as needed.
5
ATG test dose and infusion
Horse ATG is given by drip over 4–5 days with steroids to prevent reactions.
6
Cyclosporine and eltrombopag
Cyclosporine tablets start and continue for at least 12 months; eltrombopag is often added.
7
Supportive care
Blood and platelet transfusions, antibiotics and antifungals to prevent infection.
8
Discharge
Discharge after about 10–14 days when stable.
9
Outpatient monitoring
Twice-weekly blood counts and cyclosporine levels for the first weeks.
10
Response review
Blood counts usually start improving at 2–4 months; response assessed at 3 and 6 months.
⚖️ Treatment Options
| Treatment | What is done | Best for |
|---|---|---|
| Horse ATG + cyclosporine (± eltrombopag) | 4–5 day ATG infusion, then cyclosporine for 12+ months | Patients without a matched sibling, or over about 40 years |
| Matched sibling BMT | Stem cells from a fully matched brother or sister | Children and adults under about 40 with a matched sibling |
| Matched unrelated donor BMT | Stem cells from a registry donor | After ATG failure, or young patients without a sibling donor |
| Haploidentical (half-matched) BMT | Stem cells from a parent, child or half-matched sibling | No matched donor; ATG failure or relapse |
| Cyclosporine alone / supportive care | Tablets plus transfusions | Non-severe disease or frail patients |
📊 The RACE trial (NEJM 2022) showed that adding eltrombopag to horse ATG and cyclosporine raised the complete response rate at 3 months from about 10% to 22% and the overall response at 6 months to about 68%; matched sibling transplant gives long-term survival of about 85–90% in younger patients.
📅 Your Day-by-Day Plan in India
| Day | What happens |
|---|---|
| Day 1 | Arrival in India, airport pick-up, hotel check-in ✈️ |
| Day 2–5 | Haematology consultation, bone marrow biopsy, PNH and HLA tests |
| Day 6–7 | Treatment plan finalised; admission to isolation room |
| Day 8–12 | ATG infusion over 4–5 days with steroids and transfusions |
| Day 13–20 | Supportive care in hospital; discharge after 10–14 days |
| Week 4–6 | Outpatient blood counts and cyclosporine levels; plan for home follow-up; fly home ✈️ (BMT patients stay about 90 days) |
🌱 Recovery After Treatment
🛡️
Weeks 1–2
Hospital stay in isolation; transfusions and infection prevention.
🩸
Weeks 3–6
Outpatient blood tests twice a week; transfusions as needed.
✈️
Week 4–6
Fly home with a local haematologist plan if stable.
📈
Months 2–4
Blood counts start to rise; transfusion needs fall.
💊
Months 6–12
Cyclosporine continued, then slowly reduced over many months.
📅
Long term
Regular blood counts; watch for relapse, PNH or MDS.
🏆 Success Rate
| Outcome | Result |
|---|---|
| Overall response to horse ATG + cyclosporine | About 60–70% |
| Response with added eltrombopag | About 70–80% |
| Long-term survival after ATG (responders) | About 80–90% |
| Matched sibling BMT survival (under 40 years) | About 85–90% |
| Haploidentical BMT survival | About 75–85% in experienced centres |
Results depend on age, severity, how soon treatment starts, number of previous transfusions, infections at diagnosis and donor availability. Early treatment at an experienced centre gives the best outcome.
🩹 Risks & Possible Complications
Treatment of aplastic anaemia carries important risks, which your haematologist will explain:
- •Serious infections while counts are low – the main danger
- •ATG infusion reactions: fever, chills, rash or low blood pressure
- •Serum sickness 1–2 weeks after ATG: joint pain, rash, fever
- •Cyclosporine side effects: kidney strain, high blood pressure, gum swelling, extra hair growth
- •Relapse after ATG (about 30–35%)
- •Later change to MDS/AML or PNH (about 10–15% over 10 years after IST)
- •After BMT: graft failure and graft-versus-host disease (GVHD)
💰 Cost of Aplastic Anaemia Treatment in India
The cost of aplastic anaemia treatment in India starts from about USD 9,500 for immunosuppressive therapy with horse ATG and cyclosporine, including about 10–14 days in an isolation room. A matched sibling bone marrow transplant costs from about USD 28,000, and a haploidentical or unrelated donor transplant from about USD 38,000.
| Option / Hospital tier | Approx. cost (USD) | Hospital stay | Notes |
|---|---|---|---|
| Immunosuppressive therapy (Horse ATG + Cyclosporine) – this package | from 9,500 | 10–14 days, isolation room | 4–6 weeks in India |
| Matched Sibling (Allogeneic) Bone Marrow Transplant | from 28,000 | 30–45 days, BMT unit (HEPA) | About 90 days in India |
| Haploidentical / Unrelated Donor BMT | from 38,000 | 35–50 days, BMT unit (HEPA) | Unrelated donor search adds cost |
| Eltrombopag add-on (6 months) | 1,000 – 2,500 | Outpatient | Generic versions reduce cost |
⚠️ Final cost depends on the treatment chosen, ATG brand and dose (weight-based), transfusions needed, infections, ICU care and donor type. Quotes are confirmed after the specialist examines the patient in India.
📋 What the Package Includes
✅ Included
- ✔Haematologist consultations
- ✔Horse ATG infusion course
- ✔10–14 days in an isolation room
- ✔Steroid cover and routine medicines
- ✔Central line insertion
- ✔Routine blood tests during stay
- ✔Cyclosporine starting supply
- ✔Nursing and infection-control care
❌ Not Included
- ✖Bone marrow biopsy and genetic tests
- ✖HLA typing of patient and donors
- ✖Blood and platelet transfusions beyond standard
- ✖Eltrombopag
- ✖ICU care or treatment of severe infections
- ✖Medicines after discharge
- ✖Hotel, food and flights
✈️ Your Medical Travel Process with Satyug Healthcare
| Step | Details |
|---|---|
| 1. Send reports | Recent complete blood counts (CBC) with reticulocyte count, bone marrow biopsy report, PNH flow cytometry, any chromosome/genetic tests, transfusion history, HLA typing (if done) and details of brothers and sisters (age, blood group) for donor testing. |
| 2. Free opinion & quotes | Within 48-72 hours you receive opinions and cost estimates from 3-5 leading hospitals to compare. |
| 3. Choose hospital & doctor | We help you compare doctors, success rates, room options and total budget. |
| 4. Medical visa | The hospital issues a Visa Invitation Letter (VIL) to the Indian Embassy. The patient and up to 2 attendants apply for an e-Medical / Medical Attendant visa. |
| 5. Travel planning | Flight guidance, wheelchair assistance, airport pick-up, hotel or guest house near the hospital. |
| 6. Treatment in India | Your coordinator and interpreter stay with you for admission, treatment, discharge and billing. |
| 7. Return & follow-up | Fit-to-fly letter, medicines, and online follow-up with your doctor after you return home. |
🎒 Travel Checklist
- 📌Valid passport (6+ months) for the patient and attendants, plus 10 passport-size photos each
- 📌Medical visa / e-visa and the hospital’s Visa Invitation Letter
- 📌All blood count and bone marrow reports, transfusion records, HLA results and prescriptions
- 📌Yellow fever vaccination certificate (mandatory for travellers from African countries)
- 📌Polio vaccination certificate where applicable
- 📌Declare cash above USD 5,000 at the airport; hospitals accept wire transfer and cards
- 📌Foreigners staying longer than permitted must register with the FRRO — our team assists
⭐ Why Choose Satyug Healthcare?
🏥
Top Accredited Hospitals
BLK-Max Centre for Bone Marrow Transplant (Delhi), Max Saket, Artemis Gurugram, Fortis Memorial Gurugram, Medanta, Apollo Hospitals (Chennai), CMC Vellore, Narayana Health and Manipal Hospitals have experienced haematology and BMT units.
👨⚕️
Senior Specialists
Treatment is led by senior clinical haematologists and BMT physicians who manage aplastic anaemia and perform bone marrow transplants regularly.
💵
Transparent Pricing
Multiple written quotes to compare — no hidden charges, no extra fee for our service.
🤝
End-to-End Support
Visa, airport pick-up, accommodation, interpreter and 24/7 coordinator.
❓ Frequently Asked Questions
➤ What is the cost of aplastic anaemia treatment in India?
ATG-based immunosuppressive therapy starts from about USD 9,500. A matched sibling BMT starts from about USD 28,000 and a haploidentical or unrelated donor BMT from about USD 38,000.
➤ Which is better – ATG or bone marrow transplant?
For children and adults under about 40 with a matched brother or sister, transplant is usually preferred because it can cure the disease. For older patients or those without a matched sibling, ATG with cyclosporine (and often eltrombopag) is the first choice.
➤ How long will I be in hospital?
About 10–14 days for ATG treatment, and about 30–45 days (or 35–50 for haploidentical) for a bone marrow transplant.
➤ How long must I stay in India?
About 4–6 weeks for ATG therapy, and about 90 days for a bone marrow transplant.
➤ How quickly does ATG work?
ATG works slowly. Blood counts usually start rising after 2–4 months, so you will need transfusions for some time and must continue cyclosporine at home.
➤ What is the success rate?
About 60–80% of patients respond to ATG-based therapy. Matched sibling transplant cures about 85–90% of younger patients.
➤ Can my brother or sister be a donor?
Yes, if they are a full HLA match. Each full sibling has about a 1 in 4 chance of being a match. If none match, a parent or child can donate in a haploidentical transplant.
➤ Can aplastic anaemia come back?
Yes. About 30–35% relapse after ATG, often when cyclosporine is stopped. Many respond again to cyclosporine or a second course. Relapse after successful transplant is uncommon.
➤ Is aplastic anaemia a type of cancer?
No. It is a bone marrow failure disease, not cancer. However, a small number of patients may develop MDS or leukaemia years later, so long-term follow-up is needed.
➤ Can children be treated?
Yes. Children often do very well, especially with a matched sibling transplant. Inherited causes such as Fanconi anaemia must be ruled out first.
➤ What are the main risks?
Infections while counts are low, ATG reactions, serum sickness, and cyclosporine side effects. After transplant, graft failure and GVHD are possible.
💬 Get a Free Opinion & Cost Estimate
Send your medical reports today and receive opinions from India’s top specialists within 48-72 hours.
📞 +91-8860606766 | +91-9910655125 | ✉️ query@satyughealthcare.com
Medical disclaimer: This page is for general information and does not replace a consultation with a qualified specialist. Treatment plans and costs are confirmed only after the patient is examined. Sources: NCBI StatPearls: Aplastic Anemia; British Society for Haematology Guidelines for Aplastic Anaemia (Killick et al. 2016, updated); RACE trial (Peffault de Latour et al., NEJM 2022); Scheinberg et al., Horse vs Rabbit ATG (NEJM 2011); EBMT SAA Working Party data; Mayo Clinic & NHS: Aplastic anaemia. Infographics: Satyug Healthcare.
Frequently Asked Questions
The cost of aplastic anemia treatment in India starts from USD 9500. Immunosuppressive Therapy (Horse ATG + Cyclosporine): USD 9500; Matched Sibling (Allogeneic) Bone Marrow Transplant: USD 28000; Haploidentical / Unrelated Donor BMT: USD 38000. The final cost depends on the hospital, room category and medical condition.
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Aplastic anaemia treatment in India from USD 9,500. Horse ATG + cyclosporine or curative bone marrow transplant at top BMT centres, isolation rooms, visa help.
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